有研究通過在AAV 2血清型衣殼的I-587位插入不同的七聚肽重新篩選靶向血管內皮的AAV突變體,結果顯示AAV-VSSSTPR(AAV-VEC)和AAV-NNPLPQR(AAV-NEC)兩種病毒變體具有很強的選擇性,但AAV-VEC的轉導效率最高,是AAV2的2.7倍。更重要的是在GOI(Gene of Interest,簡稱GOI)為10000時,AAV-VEC的轉導效率是AAVsig的13倍。
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